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Phenotypes Associated with This Genotype
Genotype
MGI:4440753
Allelic
Composition
Scribm51206BHubr/Scrib+
Sec24bkrb/Sec24bkrb
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scribm51206BHubr mutation (0 available); any Scrib mutation (53 available)
Sec24bkrb mutation (0 available); any Sec24b mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• the organ of Corti is decreased in length compared to in wild-type mice
• at E17.5, the organ of Corti is disorganized unlike in wild-type mice
• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice
• mice exhibit a more severe phenotype compared with Sec24bkrb homozygotes
• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice

nervous system
• mice exhibit out of line and misoriented inner hair cells in the organ of Corti unlike wild-type mice
• mice exhibit a more severe phenotype compared with Sec24bkrb homozygotes
• mice exhibit supernumerary rows of outer hair cells unlike wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory