Phenotypes Associated with This Genotype

Genotype
MGI:4440454

• Allelic Composition: Dck^tm1.1Radu/Dck^tm1.1Radu
• Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus morphology ( J:158373 )

• lack the normal corticomedullary organization and appear less basophilic

thymus hypoplasia ( J:158373 )

• 6-8 weeks of age are severely microthymic, 90-fold fewer cells

increased pro-B cell number ( J:158373 )

• an increase in the percentages of Hardy fraction A-C cells (CD43+), containing the pro-B populations

abnormal T cell differentiation ( J:158373 )

• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population

abnormal double-negative T cell morphology ( J:158373 )

• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population

increased double-negative T cell number ( J:158373 )

• greater than a 10-fold increase in the DN fraction

decreased double-positive T cell number ( J:158373 )

• large reduction in the percentages of DP cells

decreased B cell number ( J:158373 )

• in spleen and lymph node

decreased pre-B cell number ( J:158373 )

• a decrease in the percentage of pre-B late cells (Hardy Fraction D, CD43-)

decreased T cell number ( J:158373 )

• decrease in the number of T cells in the peripheral lymph nodes

abnormal spleen morphology ( J:158373 )

• normal red and white pulp architecture is absent

increased spleen weight ( J:158373 )

• weigh about 3 times more than those from wild-type littermates

absent spleen white pulp ( J:158373 )

abnormal peripheral lymph node morphology ( J:158373 )

• structure of peripheral lymph nodes is abnormal and the number of lymph node T and B cells is decreased

hematopoietic system

abnormal thymus morphology ( J:158373 )

• lack the normal corticomedullary organization and appear less basophilic

thymus hypoplasia ( J:158373 )

• 6-8 weeks of age are severely microthymic, 90-fold fewer cells

increased pro-B cell number ( J:158373 )

• an increase in the percentages of Hardy fraction A-C cells (CD43+), containing the pro-B populations

abnormal T cell differentiation ( J:158373 )

• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population

abnormal double-negative T cell morphology ( J:158373 )

• significant accumulation of thymocytes at the DN3 stage reduction of the DN4 population

increased double-negative T cell number ( J:158373 )

• greater than a 10-fold increase in the DN fraction

extramedullary hematopoiesis ( J:158373 )

decreased B cell number ( J:158373 )

• in spleen and lymph node

decreased pre-B cell number ( J:158373 )

• a decrease in the percentage of pre-B late cells (Hardy Fraction D, CD43-)

decreased T cell number ( J:158373 )

• decrease in the number of T cells in the peripheral lymph nodes

decreased double-positive T cell number ( J:158373 )

• large reduction in the percentages of DP cells

reticulocytosis ( J:158373 )

• increased number of reticulocytes

abnormal spleen morphology ( J:158373 )

• normal red and white pulp architecture is absent

increased spleen weight ( J:158373 )

• weigh about 3 times more than those from wild-type littermates

absent spleen white pulp ( J:158373 )

endocrine/exocrine glands

abnormal thymus morphology ( J:158373 )

• lack the normal corticomedullary organization and appear less basophilic

thymus hypoplasia ( J:158373 )

• 6-8 weeks of age are severely microthymic, 90-fold fewer cells

growth/size/body

increased spleen weight ( J:158373 )

• weigh about 3 times more than those from wild-type littermates