Mouse Genome Informatics
cx
    Lgi1tm1.1Jkc/Lgi1tm1.1Jkc
Tyrc-Brd/Tyrc-Brd

B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• at 12 to 20 days of age, mice exhibit myoclonic seizures accompanied by rapid jumping and running and die shortly after

nervous system
N
• mice exhibit normal miniature inhibitory postsynaptic current frequency and amplitude and inhibitory postsynaptic currents (J:158715)
• mice exhibit an increase in spontaneous epileptiform discharge compared with wild-type mice
• however, firing frequency and spikes as well as resting membrane potential are normal
• at 12 to 20 days of age, mice exhibit myoclonic seizures unlike wild-type mice accompanied by rapid jumping and running and die shortly after
• AMPA receptor-mediated excitatory postsynaptic currents are larger than in wild-type mice
• NMDA receptor-mediated excitatory postsynaptic currents are larger than in wild-type mice
• mice exhibit increased frequency of miniature excitatory postsynaptic currents compared with wild-type mice

growth/size/body
• slight in some mice

behavior/neurological
• mice exhibit an increase in spontaneous epileptiform discharge compared with wild-type mice
• however, firing frequency and spikes as well as resting membrane potential are normal
• at 12 to 20 days of age, mice exhibit myoclonic seizures unlike wild-type mice accompanied by rapid jumping and running and die shortly after

pigmentation
• mice exhibit cream-colored coats compared to the white-coated C57BL/6-Tyrc-Brd control mice
• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice

vision/eye
• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyrc-Brd control mice

integument
• mice exhibit cream-colored coats compared to the white-coated C57BL/6-Tyrc-Brd control mice

Mouse Models of Human Disease
OMIM IDRef(s)
Epilepsy, Familial Temporal Lobe, 1; ETL1 600512 J:158715