Phenotypes Associated with This Genotype

Genotype
MGI:4439476

• Allelic Composition: Trpv2^tm1Mijc/Trpv2^tm1Mijc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158505 )

• L. monocytogenes-infected mice die sooner than similarly treated wild-type mice

immune system

impaired macrophage chemotaxis ( J:158505 )

• towards 10% fetal calf serum in a filter migration assay

impaired macrophage phagocytosis ( J:158505 )

• macrophage binding and phagocytosis of Ig-coated latex beads are reduced compared with wild-type cells

• L. monocytogenes-exposed macrophages uptake 92% fewer bacteria than similarly exposed wild-type cells

• however, treatment with KCL rescues bead binding and phagocytosis

increased susceptibility to bacterial infection ( J:158505 )

• L. monocytogenes-infected mice exhibit a 6000% higher bacterial load compared with similarly treated wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:158505 )

• L. monocytogenes-infected mice die sooner than similarly treated wild-type mice

growth/size/body

decreased body weight ( J:158505 )

• mice weight 10% less than wild-type mice

cellular

impaired macrophage chemotaxis ( J:158505 )

• towards 10% fetal calf serum in a filter migration assay

impaired macrophage phagocytosis ( J:158505 )

• macrophage binding and phagocytosis of Ig-coated latex beads are reduced compared with wild-type cells

• L. monocytogenes-exposed macrophages uptake 92% fewer bacteria than similarly exposed wild-type cells

• however, treatment with KCL rescues bead binding and phagocytosis

hematopoietic system

impaired macrophage chemotaxis ( J:158505 )

• towards 10% fetal calf serum in a filter migration assay

impaired macrophage phagocytosis ( J:158505 )

• macrophage binding and phagocytosis of Ig-coated latex beads are reduced compared with wild-type cells

• L. monocytogenes-exposed macrophages uptake 92% fewer bacteria than similarly exposed wild-type cells

• however, treatment with KCL rescues bead binding and phagocytosis