Phenotypes Associated with This Genotype

Genotype
MGI:4438913

• Allelic Composition: Creb3l1^tm1Kaim/Creb3l1^tm1Kaim
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone mineral density ( J:158242 )

• bone mineral density is decreased compared to in wild-type mice

decreased compact bone thickness ( J:158242 )

abnormal osteoblast morphology ( J:158242 )

• osteoblasts contain enlarged rough endoplasmic reticulum unlike wild-type cells

abnormal osteoblast differentiation ( J:158242 )

• cultured bone stromal cells produce fewer colony forming unit-osteoblasts compared with similarly treated wild-type cells

• however, early osteoblast differentiation is normal

decreased trabecular bone thickness ( J:158242 )

decreased bone mineralization ( J:158242 )

• bone apposition rate is decreased compared to in wild-type mice

decreased bone ossification ( J:158242 )

• mice exhibit decreased osteogenesis compared with wild-type mice

• however, bone resorption is normal

fragile skeleton ( J:158242 )

• mice exhibit focal swelling of limbs and heels due to fractures unlike wild-type mice

hematopoietic system

abnormal bone marrow cell morphology/development ( J:158242 )

• cultured bone stromal cells produce fewer colony forming unit-osteoblasts compared with similarly treated wild-type cells

growth/size/body

postnatal growth retardation ( J:158242 )

cellular

abnormal osteoblast differentiation ( J:158242 )

• cultured bone stromal cells produce fewer colony forming unit-osteoblasts compared with similarly treated wild-type cells

• however, early osteoblast differentiation is normal