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Phenotypes Associated with This Genotype
Genotype
MGI:4438459
Allelic
Composition
Col8a2Aca23/Col8a2+
Genetic
Background
C57BL/6J-Col8a2Aca23
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col8a2Aca23 mutation (1 available); any Col8a2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice do not develop opacities and remain transparent at least until 15 months
• mice exhibit normal corneal epithelium proliferation, eye fundus, and visual acuity
• eye abnormalities are less severe than in homozygotes
• mice exhibit enlarged axis compared with wild-type mice
• mice exhibit reduced epithelium compared with wild-type mice
• contains globoid, keratoglobus-like protrusion

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Corneal Dystrophy, Fuchs Endothelial, 1; FECD1 136800 J:158259


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory