Phenotypes Associated with This Genotype

Genotype
MGI:4438385

• Allelic Composition: H2ax^tm1Fwa/H2ax^tm1Fwa
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

chromosomal instability ( J:84879 )

• 52% of splenic T cells exhibit chromosomal abnormalities, including chromosomal gaps, fusions, fragments, and detached centromeres, compared to 11% in wild-type

growth/size/body

decreased body size ( J:84879 )

hematopoietic system

abnormal class switch recombination ( J:84879 )

• impaired class-switch recombination

decreased lymphocyte cell number ( J:84879 )

immune system

abnormal class switch recombination ( J:84879 )

• impaired class-switch recombination

decreased lymphocyte cell number ( J:84879 )

neoplasm

increased T cell derived lymphoma incidence ( J:84879 )

• 3 mutants succumb to aggressive CD4+/CD8+ thymic lymphomas, harboring translocations involving chromosomes 14 and 16, indicating a low level of increased tumor incidence

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:84879 )

• 3 mutants succumb to aggressive CD4+/CD8+ thymic lymphomas, harboring translocations involving chromosomes 14 and 16, indicating a low level of increased tumor incidence