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Phenotypes Associated with This Genotype
Genotype
MGI:4438111
Allelic
Composition
Ncf1tm1Shl/Ncf1tm1Shl
Genetic
Background
B6.129S2-Ncf1tm1Shl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncf1tm1Shl mutation (2 available); any Ncf1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• greatly reduced after myocardial infarction relative to controls
• weight gain on a high fat diet is more moderate than in controls

respiratory system
• airway smooth muscle length and area are significantly increased
• 17% more area in the trachea is occupied by smooth muscle
• 40% greater maximal stress resulting from 10/sec electric field stimulations
• increase is not significant when corrected for increased smooth muscle area
• reduced rate of relaxation
• baseline total lung resistance is reduced
• baseline static lung compliance is increased

cardiovascular system
• angiogenic response after carotid ligation is more moderate than in controls
• greatly reduced after myocardial infarction relative to controls
• left ventricular cavity dilation is substantially reduced after myocardial infarction
• left ventricular ejection fraction is better preserved than in infarcted controls
• improved survival rate (72% vs 48% for controls)
• reduced apoptosis at the left ventricular border zone
• myocardial hypertrophy largely prevented
• elevated blood pressure between 6-12 weeks of age
• blood pressure slowly decreases with age
• endothelium dependent relaxation by acetyl choline in aortic rings is attenuated at 12 weeks
• more moderate neointimal formation after carotid ligation relative to controls

immune system
• inflammatory response after carotid ligation is more moderate than in controls
• lung granuloma formation after 12 weeks if not treated with antibiotics
• lung granuloma formation after 20 weeks when treated with antibiotics

homeostasis/metabolism
• improved survival rate (72% vs 48% for controls)
• reduced apoptosis at the left ventricular border zone
• myocardial hypertrophy largely prevented
• more moderate neointimal formation after carotid ligation relative to controls
• elevated ACE activity in tissues at 12 weeks of age

nervous system
• long lasting phase of LTP is slightly enhanced
• completely abrogated in hippocampal slices

behavior/neurological
• impaired contextual fear response
• cued memory is normal
• small but significant deficits in early training trials in water maze tests
• spatial learning impairments
• slightly increased time spent in the center in an open field test

muscle
• left ventricular ejection fraction is better preserved than in infarcted controls
• endothelium dependent relaxation by acetyl choline in aortic rings is attenuated at 12 weeks
• airway smooth muscle length and area are significantly increased
• 17% more area in the trachea is occupied by smooth muscle

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic granulomatous disease DOID:3265 OMIM:PS306400
J:111142


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory