Phenotypes for Gna12 Gna13 Grhl3 MGI:4438090 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13^tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:157446 )

• mutants die by 10.5 days post coitus (dpc)

embryo

abnormal embryo development ( J:157446 )

• embryos display turning defects and other defects, but the hindbrain neuropore is closed in mutants at 10.5 dpc

abnormal embryo turning ( J:157446 )

• embryos show turning defects

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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