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Phenotypes Associated with This Genotype
Genotype
MGI:4437582
Allelic
Composition
plt/plt
Genetic
Background
either: B6.DDD-plt or C.DDD-plt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
plt mutation (3 available); any plt mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• as early as 5 weeks of age, mice exhibit lesions in exocrine glands unlike wild-type mice
• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

immune system
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice
• mice exhibit autoimmune exocrinopathy unlike wild-type mice
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

homeostasis/metabolism
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

digestive/alimentary system
• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

vision/eye
• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

cellular
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

hematopoietic system
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:110910


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory