Mouse Genome Informatics
hm
    plt/plt
either: B6.DDD-plt or C.DDD-plt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• as early as 5 weeks of age, mice exhibit lesions in exocrine glands unlike wild-type mice
• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

immune system
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice
• mice exhibit autoimmune exocrinopathy unlike wild-type mice
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

homeostasis/metabolism
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

digestive/alimentary system
• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

vision/eye
• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

cellular
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

hematopoietic system
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:110910