Phenotypes Associated with This Genotype

Genotype
MGI:4437119

• Allelic Composition: Maged1^tm1.1Urfm/Maged1^tm1.1Urfm
• Genetic Background: B6.129P2-Maged1^tm1.1Urfm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:157604 )

♀N • unlike in Ngfr null mice, no defect in neuronal growth is detected

decreased neuron apoptosis ( J:157604 )

♀ • motorneuron apoptosis is sharply reduced

abnormal superior cervical ganglion morphology ( J:157604 )

♀ • between P3 and P23, the number of sympathetic neurons in the NRAGE null animals drops but remains still significantly higher than in wild-type littermates

abnormal sympathetic neuron physiology ( J:157604 )

♀ • the effect of brain-derived neurotrophic factor is significantly reduced, exposure to the ligand causes only a twofold increase in superior cervical ganglia cell death in primary cell culture

integument

abnormal hair cycle catagen phase ( J:157604 )

♀ • profound delay in catagen-dependent dermal thinning, a reduction in the hair follicle bulb volume and hair follicle shortening during the first hair follicle cycle and after depilation

cellular

decreased neuron apoptosis ( J:157604 )

♀ • motorneuron apoptosis is sharply reduced