Phenotypes Associated with This Genotype

Genotype
MGI:4437050

• Allelic Composition: Mirc30^tm1.2Rdf/Mirc30^tm1.2Rdf
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell proliferation ( J:156946 )

• cells synthesize DNA earlier based upon BrdU labeling

• expression analysis suggests defects in regulation of G0/G1 to S phase transition

increased B cell number ( J:156946 )

• monoclonal B cell lymphocytosis in about 5% of mice

increased B-1a cell number ( J:156946 )

• increased number of poly/oligoclonal cells in the peritoneal cavity at 12 months

• at 15-18 months, increased clonal population in the peripheral blood

increased spleen white pulp amount ( J:156946 )

• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice

immune system

abnormal B cell proliferation ( J:156946 )

• cells synthesize DNA earlier based upon BrdU labeling

• expression analysis suggests defects in regulation of G0/G1 to S phase transition

increased B cell number ( J:156946 )

• monoclonal B cell lymphocytosis in about 5% of mice

increased B-1a cell number ( J:156946 )

• increased number of poly/oligoclonal cells in the peritoneal cavity at 12 months

• at 15-18 months, increased clonal population in the peripheral blood

increased spleen white pulp amount ( J:156946 )

• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice

neoplasm

increased leukemia incidence ( J:156946 )

• a fraction of mice have histological feature of small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL)

increased B cell derived lymphoma incidence ( J:156946 )

• some of the CD5 negative tumors showed a mature B cell phenotype histologically reminiscent of human diffuse large B cell lymphoma (DLBCL), non-Hodgkin lymphoma

• a minority of CD5 negative tumors showed plasmacytic features similar to lymphoplasmacytic lymphoma

cellular

abnormal B cell proliferation ( J:156946 )

• cells synthesize DNA earlier based upon BrdU labeling

• expression analysis suggests defects in regulation of G0/G1 to S phase transition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:156946