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Phenotypes Associated with This Genotype
Genotype
MGI:4437050
Allelic
Composition
Mirc30tm1.2Rdf/Mirc30tm1.2Rdf
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc30tm1.2Rdf mutation (0 available); any Mirc30 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cells synthesize DNA earlier based upon BrdU labeling
• expression analysis suggests defects in regulation of G0/G1 to S phase transition

hematopoietic system
• cells synthesize DNA earlier based upon BrdU labeling
• expression analysis suggests defects in regulation of G0/G1 to S phase transition
• monoclonal B cell lymphocytosis in about 5% of mice
• increased number of poly/oligoclonal cells in the peritoneal cavity at 12 months
• at 15-18 months, increased clonal population in the peripheral blood
• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice

immune system
• cells synthesize DNA earlier based upon BrdU labeling
• expression analysis suggests defects in regulation of G0/G1 to S phase transition
• monoclonal B cell lymphocytosis in about 5% of mice
• increased number of poly/oligoclonal cells in the peritoneal cavity at 12 months
• at 15-18 months, increased clonal population in the peripheral blood
• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice

neoplasm
• a fraction of mice have histological feature of small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL)
• some of the CD5 negative tumors showed a mature B cell phenotype histologically reminiscent of human diffuse large B cell lymphoma (DLBCL), non-Hodgkin lymphoma
• a minority of CD5 negative tumors showed plasmacytic features similar to lymphoplasmacytic lymphoma


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory