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Phenotypes Associated with This Genotype
Genotype
MGI:4436773
Allelic
Composition
Ffar2tm2Lex/Ffar2tm2Lex
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ffar2tm2Lex mutation (0 available); any Ffar2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following addition of 4% dextrane sodium sulfate to the drinking water, mice die between days 6 and 8 from sepsis, whereas all wild-type mice survived until day 10 when the experiment was stopped

digestive/alimentary system
• less rectal bleeding in repeated administrations of 2% dextrane sodium sulfate for 30 days compared to wild-type
• significantly decreased endoscopic score following addition of 4% dextrane sodium sulfate to the drinking water
• significantly decreased endoscopic score and increased colon length after repeated administrations of 2% dextrane sodium sulfate for 30 days
• less diarrhea in mice administered 2% dextrane sodium sulfate for 30 days compared to wild-type
• 4% dextrane sodium sulfate (DSS) added to the drinking water induces less intestinal damage although disease activity index is elevated after day 6 due to sepsis
• repeated administrations of 2% dextrane sodium sulfate for 30 days results in significantly milder disease activity index compared to similarly treated wild-type mice
• distal colon shows reduced tissue damage and inflammatory cell infiltration after 4% dextrane sodium sulfate added to the drinking water
• repeated administrations of 2% dextrane sodium sulfate for 30 days results in less inflammatory mucosal signs

immune system
• propionate or butyrate stimulation does not increase chemotactic migration as is observed in wild-type mice
• myeloperoxidase activity levels are significantly reduced during treatment with 4% dextrane sodium sulfate in homogenized colonic tissue
• the amount of polymorphonuclear leukocytes in the submucosal tissue is significantly reduced compared with wild-type mice after 4% dextrane sodium sulfate added to the drinking water
• L-selectin protein levels on the cell surface of polymorphonuclear are elevated compared to wild-type after 1 hour of stimulation with short chain fatty acids.
• TNF-alpha concentrations are diminished after repeated administrations of 2% dextrane sodium sulfate for 30 days compared to wild-type
• TNF-alpha levels are highly elevated during treatment with 4% dextrane sodium sulfate in the drinking water
• level of TNF-alpha in colonic organ cultures is significantly reduced
• less inflammation in animals on day 6 after 4% dextrane sodium sulfate added to the drinking water
• 4% dextrane sodium sulfate (DSS) added to the drinking water induces less intestinal damage although disease activity index is elevated after day 6 due to sepsis
• repeated administrations of 2% dextrane sodium sulfate for 30 days results in significantly milder disease activity index compared to similarly treated wild-type mice
• distal colon shows reduced tissue damage and inflammatory cell infiltration after 4% dextrane sodium sulfate added to the drinking water
• repeated administrations of 2% dextrane sodium sulfate for 30 days results in less inflammatory mucosal signs
• 16S rDNA bacterial signatures of Clostridium spp in liver and spleen after 4% dextrane sodium sulfate added to the drinking water

growth/size/body
• more weight loss in response to 4% dextrane sodium sulfate added to the drinking water
• repeated administrations of 2% dextrane sodium sulfate for 30 days results in less weight loss than in wild-type

cardiovascular system
• less rectal bleeding in repeated administrations of 2% dextrane sodium sulfate for 30 days compared to wild-type

hematopoietic system
• propionate or butyrate stimulation does not increase chemotactic migration as is observed in wild-type mice
• myeloperoxidase activity levels are significantly reduced during treatment with 4% dextrane sodium sulfate in homogenized colonic tissue
• the amount of polymorphonuclear leukocytes in the submucosal tissue is significantly reduced compared with wild-type mice after 4% dextrane sodium sulfate added to the drinking water
• L-selectin protein levels on the cell surface of polymorphonuclear are elevated compared to wild-type after 1 hour of stimulation with short chain fatty acids.

homeostasis/metabolism
• TNF-alpha concentrations are diminished after repeated administrations of 2% dextrane sodium sulfate for 30 days compared to wild-type
• TNF-alpha levels are highly elevated during treatment with 4% dextrane sodium sulfate in the drinking water
• following addition of 4% dextrane sodium sulfate to the drinking water, mice die between days 6 and 8 from sepsis, whereas all wild-type mice survived until day 10 when the experiment was stopped

cellular
• propionate or butyrate stimulation does not increase chemotactic migration as is observed in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory