Analysis Tools
mortality/aging
| N |
• mice do not exhibit premature death
|
nervous system
| N |
• Purkinje cells exhibit normal electrophysiology
|
microgliosis
(
J:157113
)
|
• as early as 5.5 to 7 weeks, mice exhibit loss of Purkinje cells unlike wild-type mice
• by 10 weeks, mice exhibit a 15% loss of Purkinje cells in lobule X compared with wild-type mice
• however, no further loss of Purkinje cells in lobule X occur between 10 and 20 weeks
• Purkinje cell loss in lobules II-V is greater than 75% at 10 weeks and approaches 100% by 15 weeks
|
behavior/neurological
|
• by 10 weeks, mice exhibit difficulties traversing a balance beam unlike wild-type mice
• by 15 weeks, mice exhibit impaired performance on a rotarod compared with wild-type mice
• motor defects are age-dependent
|
homeostasis/metabolism
|
• mice exhibit age-dependent unesterified cholesterol accumulation in Purkinje cells unlike in wild-type mice
|
growth/size/body
| N |
• mice do not exhibit weight loss
|
immune system
microgliosis
(
J:157113
)
hematopoietic system
microgliosis
(
J:157113
)
