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Phenotypes Associated with This Genotype
Genotype
MGI:4431053
Allelic
Composition		 Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube closure ( J:157446 )
• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen

nervous system
abnormal neural tube closure ( J:157446 )
• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen
exencephaly ( J:157446 )
• observed with 10% frequency in viable embryos collected at 14.5 days post coitus

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory