Mouse Genome Informatics
hm
    Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7tm1Rfor
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
N
• no single positive T cell abnormalities other than the migration defect from cortex to medulla of the thymus (J:93960)
• single positive T cells fail to localize to the medulla of the thymus in newborns (J:93960)
• single positive T cells are retained in the cortex of the thymus (J:93960)
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice (J:110910)
• single positive thymocytes are retained by the cortex rather than migrating to the medulla
• reduced in size in the adult thymus
• medullary volume is about 50% that found in controls
• 18 h after stimulation by fluorescein isothiocyanate skin painting dendritic cells fail to reach the lymph nodes
• this defect can be partially overcome by use of high antigen doses
• mice exhibit autoimmune exocrinopathy unlike wild-type mice
• mice exhibit periductal lymphocyte infiltration in the lacrimal, parotid, and submandibular glands unlike wild-type mice
• parotid and submandicular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit sialadenitis unlike wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

endocrine/exocrine glands
• parotid and submandicular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit sialadenitis unlike wild-type mice
• as early as 5 weeks of age, mice exhibit lesions in exocrine glands unlike wild-type mice
• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
• single positive thymocytes are retained by the cortex rather than migrating to the medulla
• reduced in size in the adult thymus
• medullary volume is about 50% that found in controls
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

digestive/alimentary system
• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
• parotid and submandicular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit sialadenitis unlike wild-type mice

hematopoietic system
• single positive T cells fail to localize to the medulla of the thymus in newborns (J:93960)
• single positive T cells are retained in the cortex of the thymus (J:93960)
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice (J:110910)
• single positive thymocytes are retained by the cortex rather than migrating to the medulla
• reduced in size in the adult thymus
• medullary volume is about 50% that found in controls

homeostasis/metabolism
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

vision/eye
• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

cellular
• single positive T cells fail to localize to the medulla of the thymus in newborns (J:93960)
• single positive T cells are retained in the cortex of the thymus (J:93960)
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice (J:110910)

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:110910