Phenotypes Associated with This Genotype

Genotype
MGI:4430601

• Allelic Composition: Ccr7^tm1Rfor/Ccr7^tm1Rfor
• Genetic Background: B6.129P2-Ccr7^tm1Rfor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:93960 )

N • no single positive T cell abnormalities other than the migration defect from cortex to medulla of the thymus

abnormal leukocyte migration ( J:93960 , J:110910 )

• single positive T cells fail to localize to the medulla of the thymus in newborns (J:93960)

• single positive T cells are retained in the cortex of the thymus (J:93960)

• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice (J:110910)

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls

abnormal dendritic cell physiology ( J:183989 )

• 18 h after stimulation by fluorescein isothiocyanate skin painting dendritic cells fail to reach the lymph nodes

• this defect can be partially overcome by use of high antigen doses

increased susceptibility to autoimmune disorder ( J:110910 )

• mice exhibit autoimmune exocrinopathy unlike wild-type mice

increased inflammatory response ( J:110910 )

salivary gland inflammation ( J:110910 )

• mice exhibit sialadenitis unlike wild-type mice

parotid gland inflammation ( J:110910 )

• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

submandibular gland inflammation ( J:110910 )

• submandicular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

lacrimal gland inflammation ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

• mice exhibit dacryoadenitis unlike wild-type mice

endocrine/exocrine glands

salivary gland inflammation ( J:110910 )

• mice exhibit sialadenitis unlike wild-type mice

parotid gland inflammation ( J:110910 )

• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

submandibular gland inflammation ( J:110910 )

• submandicular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls

abnormal exocrine gland morphology ( J:110910 )

• as early as 5 weeks of age, mice exhibit lesions in exocrine glands unlike wild-type mice

abnormal parotid gland morphology ( J:110910 )

• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice

abnormal submandibular gland morphology ( J:110910 )

• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice

abnormal lacrimal gland morphology ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice

lacrimal gland inflammation ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

• mice exhibit dacryoadenitis unlike wild-type mice

digestive/alimentary system

abnormal parotid gland morphology ( J:110910 )

• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice

abnormal submandibular gland morphology ( J:110910 )

• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice

salivary gland inflammation ( J:110910 )

• mice exhibit sialadenitis unlike wild-type mice

parotid gland inflammation ( J:110910 )

• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

submandibular gland inflammation ( J:110910 )

• submandicular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:93960 , J:110910 )

• single positive T cells fail to localize to the medulla of the thymus in newborns (J:93960)

• single positive T cells are retained in the cortex of the thymus (J:93960)

• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice (J:110910)

abnormal thymus cortex morphology ( J:93960 )

• single positive thymocytes are retained by the cortex rather than migrating to the medulla

small thymus medulla ( J:93960 )

• reduced in size in the adult thymus

• medullary volume is about 50% that found in controls

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:110910 )

• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

vision/eye

abnormal lacrimal gland morphology ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice

lacrimal gland inflammation ( J:110910 )

• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

• mice exhibit dacryoadenitis unlike wild-type mice

cellular

abnormal leukocyte migration ( J:93960 , J:110910 )

• single positive T cells fail to localize to the medulla of the thymus in newborns (J:93960)

• single positive T cells are retained in the cortex of the thymus (J:93960)

• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice (J:110910)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:110910