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Phenotypes Associated with This Genotype
Genotype
MGI:4430413
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0
Genetic
Background
involves: C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich mutation (0 available); any Gt(ROSA)26Sor mutation (305 available)
Tg(Ins2-cre)23Herr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight of neonates is normal (J:146650)
• growth retardation after birth (J:146650)
• body weight is 50% of controls by three months (J:146650)
• pancreas weight/body weight ratio is normal (J:146650)
• body weight of neonates is normal (J:146650)
• growth retardation after birth (J:146650)
• body weight is 50% of controls by three months (J:146650)
• pancreas weight/body weight ratio is normal (J:146650)

homeostasis/metabolism
• by 6 weeks of age loss of response to injected glucose (J:146650)
• by 6 weeks of age loss of response to injected glucose (J:146650)
• dramatic lowering of glucose levels after insulin injection (J:146650)
• dramatic lowering of glucose levels after insulin injection (J:146650)
• blood glucose is over 200mg/dl within 2 weeks of birth (J:146650)
• progressively increases to over 600mg/dl by 2 months (J:146650)
• blood glucose is over 200mg/dl within 2 weeks of birth (J:146650)
• progressively increases to over 600mg/dl by 2 months (J:146650)
• levels become undetectable as diabetes becomes more severe (J:146650)
• levels become undetectable as diabetes becomes more severe (J:146650)
• significantly elevated early in diabetes development (J:146650)
• significantly elevated early in diabetes development (J:146650)
• plasma insulin levels decrease with time (J:146650)
• plasma insulin levels decrease with time (J:146650)

endocrine/exocrine glands
• alpha cells infiltrate center of islets after the onset of diabetes (J:146650)
• alpha cells infiltrate center of islets after the onset of diabetes (J:146650)
• are lost as diabetes becomes more severe (J:146650)
• are lost as diabetes becomes more severe (J:146650)
• beta cells are lost as diabetes develops (J:146650)
• beta cells are lost as diabetes develops (J:146650)
• number of islet is reduced by 50% early in diabetes and by more than 90% later (J:146650)
• number of islet is reduced by 50% early in diabetes and by more than 90% later (J:146650)
• islet mass decreases to about 10% of controls (J:146650)
• islet mass decreases to about 10% of controls (J:146650)
• pancreas weight relative to controls becomes reduced over time (J:146650)
• pancreas weight/body weight ratio is normal (J:146650)
• pancreas weight relative to controls becomes reduced over time (J:146650)
• pancreas weight/body weight ratio is normal (J:146650)
• insulin content of pancreas drops to about 10% of control levels (J:146650)
• insulin content of pancreas drops to about 10% of control levels (J:146650)
• by 6 weeks of age loss of response to injected glucose (J:146650)
• by 6 weeks of age loss of response to injected glucose (J:146650)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Permanent Neonatal; PNDM 606176 J:146650


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory