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Phenotypes Associated with This Genotype
involves: C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Ins2-cre)23Herr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• body weight of neonates is normal
• growth retardation after birth
• body weight is 50% of controls by three months
• pancreas weight/body weight ratio is normal

• by 6 weeks of age loss of response to injected glucose
• dramatic lowering of glucose levels after insulin injection
• blood glucose is over 200mg/dl within 2 weeks of birth
• progressively increases to over 600mg/dl by 2 months
• levels become undetectable as diabetes becomes more severe
• significantly elevated early in diabetes development
• plasma insulin levels decrease with time

endocrine/exocrine glands
• alpha cells infiltrate center of islets after the onset of diabetes
• are lost as diabetes becomes more severe
• beta cells are lost as diabetes develops
• number of islet is reduced by 50% early in diabetes and by more than 90% later
• islet mass decreases to about 10% of controls
• pancreas weight relative to controls becomes reduced over time
• pancreas weight/body weight ratio is normal
• insulin content of pancreas drops to about 10% of control levels
• by 6 weeks of age loss of response to injected glucose

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
permanent neonatal diabetes mellitus DOID:0060639 OMIM:606176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory