Mouse Genome Informatics
cn
    Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+
Tg(Ins2-cre)23Herr/0

involves: C57BL/6 * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• body weight of neonates is normal
• growth retardation after birth
• body weight is 50% of controls by three months
• pancreas weight/body weight ratio is normal

homeostasis/metabolism
• by 6 weeks of age loss of response to injected glucose
• dramatic lowering of glucose levels after insulin injection
• blood glucose is over 200mg/dl within 2 weeks of birth
• progressively increases to over 600mg/dl by 2 months
• levels become undetectable as diabetes becomes more severe
• significantly elevated early in diabetes development
• plasma insulin levels decrease with time

endocrine/exocrine glands
• alpha cells infiltrate center of islets after the onset of diabetes
• are lost as diabetes becomes more severe
• beta cells are lost as diabetes develops
• number of islet is reduced by 50% early in diabetes and by more than 90% later
• islet mass decreases to about 10% of controls
• pancreas weight relative to controls becomes reduced over time
• pancreas weight/body weight ratio is normal
• insulin content of pancreas drops to about 10% of control levels
• by 6 weeks of age loss of response to injected glucose

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Permanent Neonatal; PNDM 606176 J:146650