Phenotypes Associated with This Genotype

Genotype
MGI:4430378

• Allelic Composition: Igf1^tm1Dlr/Igf1^tm1Dlr; Tg(Serpina1e-cre/ERT)1Sykr/0
• Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:155733 )

N • serum adiponectin and glucose levels in obese iLID mice are comparable to lean iLID mice (iLID, inducible liver-specific IGF-1 deficiency)

increased circulating insulin level ( J:155733 )

• iLID mice fed a high calorie for 8 to 10 weeks and then injected with tamoxifen exhibit increased serum insulin levels compared to tamoxifen-treated lean mice (fed a regular diet)

decreased circulating insulin-like growth factor I level ( J:155733 )

• mutant mice (iLID, inducible liver-specific IGF-1 deficiency) fed a high calorie or regular diet for 8 to 10 weeks and then injected with tamoxifen exhibit decreased serum IGF-1 levels relative to tamoxifen-treated controls

increased circulating leptin level ( J:155733 )

• iLID mice fed a high calorie for 8 to 10 weeks and then injected with tamoxifen exhibit increased serum leptin levels compared to tamoxifen-treated lean mice (fed a regular diet)

neoplasm

neoplasm ( J:155733 )

N • tamoxifen treatment of lean or obese mice before or after injection of MC-38 colon carcinoma cells does not alter the obesity-associated increase in tumor growth in contrast to what is observed in LID (chronic liver-specific IGF-1 deficiency) mice