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Phenotypes Associated with This Genotype
Genotype
MGI:4430356
Allelic
Composition		 Irs1tm1Mfw/Irs1tm2.1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Mfw mutation (0 available); any Irs1 mutation (51 available)
Irs1tm2.1Mfw mutation (0 available); any Irs1 mutation (51 available)
Irs2tm2Mfw mutation (0 available); any Irs2 mutation (35 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating insulin level ( J:156999 )
• fasting and fed insulin concentrations are elevated
impaired glucose tolerance ( J:156999 )
• severe glucose intolerance
insulin resistance ( J:156999 )
• significant insulin resistance

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory