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Phenotypes Associated with This Genotype
Genotype
MGI:4430354
Allelic
Composition		 Irs1tm2.1Mfw/Irs1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm2.1Mfw mutation (0 available); any Irs1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic beta cell morphology ( J:156999 )
• pancreatic beta cell area increases significantly in high-fat diet fed mice

homeostasis/metabolism
increased circulating insulin level ( J:156999 )
• high-fat diet fed mice have a median fasting insulin concentration that is substantially elevated over that of wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory