Phenotypes Associated with This Genotype

Genotype
MGI:4430194

• Allelic Composition: Tg(KRT5-Stat3*A661C*N663C)1Jdg/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased keratinocyte proliferation ( J:95458 )

abnormal skin morphology ( J:95458 )

• at birth, skin vasculature is more prominent than in wild-type mice

mixed cellular infiltration to dermis ( J:95458 )

hyperkeratosis ( J:95458 )

• at 2 weeks, hyperkeratosis develops in the tail and spreads to the dorsum and hind feet unlike in wild-type mice

parakeratosis ( J:95458 )

absent epidermis stratum granulosum ( J:95458 )

acanthosis ( J:95458 )

• at 2 weeks of age

reddish skin ( J:95458 )

• at 2 weeks of age

scaly skin ( J:95458 )

• at 2 weeks of age

psoriasis ( J:95458 )

• mice develop psoriatic lesion unlike wild-type mice

• wounding induces psoriatic lesion unlike in similarly treated wild-type mice

• however, pre-treatment with a Stat3-specific decoy inhibits tape-striping induced psoriatic lesion

thick skin ( J:95458 )

• at birth

cellular

increased keratinocyte proliferation ( J:95458 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:95458