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Phenotypes Associated with This Genotype
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm2Ewj mutation (0 available); any Fgfr2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 1 of 14 mice exhibit severe brain asymmetry unlike in wild-type mice
• 1 of 14 mice exhibit mild brain asymmetry unlike in wild-type mice
• rostrocaudal brain length in many mice is decreased compared to in wild-type mice
• in 2 of 14 mice
• in 1 of 14 mice
• mice exhibit cerebral asymmetry to varying degrees compared with wild-type mice
• cerebral height in many mice is increased compared to in wild-type mice
• arched in 3 of 14 mice

• at P0, mice exhibit variation in the pattern and degree of coronal suture closure compared with wild-type mice
• mice exhibit unilateral or bilateral coronal suture synostosis unlike wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Apert Syndrome 101200 J:156940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory