Phenotypes Associated with This Genotype

Genotype
MGI:4429706

• Allelic Composition: Gpr15^tm1.1Litt/Gpr15^tm1.1Litt
• Genetic Background: B6.129P2-Gpr15^tm1.1Litt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:156845 )

N • mice are viable and fertile

increased susceptibility to bacterial infection induced morbidity/mortality ( J:199126 )

• in mice infected with Citrobacter rodentium

reproductive system

reproductive system phenotype ( J:156845 )

N • mice are viable and fertile

immune system

immune system phenotype ( J:199126 )

N • Background Sensitivity: mice on a congenic C57BL/6 background exhibit normal proportions of IFN-gamma and IL17A-producing CD4+ T cells in the large intestine lamina propria unlike mice on a mixed background

increased susceptibility to induced colitis ( J:199126 )

• mice infected with Citrobacter rodentium exhibit severe weight loss, increased inflammation, increased tissue damage, increased cytokine expression, decreased regulatory T cell numbers in the large intestine lamina propria and death compared with control mice

decreased double-negative T cell number ( J:199126 )

• in the large intestine lamina propria

• however, the numbers are normal in the small intestine

decreased CD4-positive, alpha-beta T cell number ( J:199126 )

• small reduction in the large intestine lamina propria

• however, numbers are normal in the small intestine propria and spleen

increased CD8-positive, alpha-beta T cell number ( J:199126 )

• in the large intestine lamina propria

• however, the numbers are normal in the small intestine

decreased regulatory T cell number ( J:199126 )

• reduced percentage and cell number in the large intestine lamina propria

• in mice infected with Citrobacter rodentium

• however, percentages are normal in the small intestine propria and spleen

abnormal regulatory T cell physiology ( J:199126 )

• regulatory T cells transferred into Rag2 null mice fail to reduce induced colitis unlike wild-type cells

• however, regulatory T cell exhibit normal ability to suppress naive T cell proliferation

increased susceptibility to bacterial infection ( J:199126 )

• mice infected with Citrobacter rodentium exhibit severe weight loss, increased inflammation, increased tissue damage, increased cytokine expression, decreased regulatory T cell numbers in the large intestine lamina propria and death compared with control mice

• however, pathogen load in the large intestine and spleen is normal

increased susceptibility to bacterial infection induced morbidity/mortality ( J:199126 )

• in mice infected with Citrobacter rodentium

digestive/alimentary system

increased susceptibility to induced colitis ( J:199126 )

• mice infected with Citrobacter rodentium exhibit severe weight loss, increased inflammation, increased tissue damage, increased cytokine expression, decreased regulatory T cell numbers in the large intestine lamina propria and death compared with control mice

growth/size/body

increased susceptibility to weight loss ( J:199126 )

• severe in mice infected with Citrobacter rodentium

hematopoietic system

decreased double-negative T cell number ( J:199126 )

• in the large intestine lamina propria

• however, the numbers are normal in the small intestine

decreased CD4-positive, alpha-beta T cell number ( J:199126 )

• small reduction in the large intestine lamina propria

• however, numbers are normal in the small intestine propria and spleen

increased CD8-positive, alpha-beta T cell number ( J:199126 )

• in the large intestine lamina propria

• however, the numbers are normal in the small intestine

decreased regulatory T cell number ( J:199126 )

• reduced percentage and cell number in the large intestine lamina propria

• in mice infected with Citrobacter rodentium

• however, percentages are normal in the small intestine propria and spleen

abnormal regulatory T cell physiology ( J:199126 )

• regulatory T cells transferred into Rag2 null mice fail to reduce induced colitis unlike wild-type cells

• however, regulatory T cell exhibit normal ability to suppress naive T cell proliferation

abnormal bone marrow cell physiology ( J:199126 )

• bone marrow transplanted into irradiated Foxp3^sf mice confers increased susceptibility to Citrobacter rodentium-induced colitis