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Phenotypes Associated with This Genotype
Genotype
MGI:4429667
Allelic
Composition
Drd2tm1Low/Drd2tm1Low
Genetic
Background
B6.129S2-Drd2tm1Low
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Low mutation (1 available); any Drd2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit a normal saccharin and quinine preference and locomotor depressant response to SCH-23390 treatment (J:50787)
• mice exhibit normal basic motor skills without tremor, ataxia, or abnormal stance or posture (J:103181)
• mice exhibit normal novel odor habituation and odor sensitivity (J:110704)
• mice exhibit normal tactile responsivity, trigeminal nerve response, or aversive taste reactivity (J:110704)
• preference ratio is less than 0.4
• mice consume less 6% and 10% ethanol solution compared with wild-type mice
• amphetamine-treated mice fail to exhibit a reduction in prepulse inhibition unlike similarly treated wild-type mice
• however, amphetamine-treated mice exhibit normal reduction in startle reactivity
• ethanol-treated mice fail to exhibit a locomotor depressant responses unlike similarly treated wild-type mice
• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice
• during reversal learning trials, mice preserve unreinforced behavior and commit more reversal errors across reversal sessions compared with wild-type mice
• mice exhibit reduced performance in an odor-driven stimulus-discrimination, operant task compared with wild-type mice
• mice fail to exhibit an increase in investigation of a novel odor unlike wild-type mice
• mice exhibit an impairment in olfactory discrimination compared with wild-type mice
• mice fail to exhibit increased investigation of an object with a novel scent versus one with s familiar scent unlike wild-type mice
• however, mice exhibit normal exploration behavior
• mice exhibit reduced acoustic startle response amplitude compared with wild-type mice
• on days 2 and 3, but not 4, of a rotarod test
• mice exhibit decreased horizontal distance, initiation of movement, rearing, and duration of horizontal movement compared with C57BL/6 mice (J:47001)
• mice exhibit reduced mean distance, number of movements, and time in motion compared with wild-type mice (J:50787)
• however, the movement speed and movement length are normal (J:50787)
• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice
• mice exhibit reduced initiation of movement compared with C57BL/6 mice (J:47001)
• mice exhibit decreased initiation of movement compared with wild-type mice (J:103181)

nervous system
• mice fail to exhibit an increase in paired pulse ratio during development unlike wild-type mice
• mice fail to exhibit an increase in paired pulse ratio during development unlike wild-type mice
• mice subjected to high-frequency stimulation fail to exhibit a change in paired pulse ratio unlike similarly treated wild-type mice
• mice fail to exhibit a decrease in the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) during development unlike wild-type mice
• at P21 to 27, mice exhibit increased spontaneous postsynaptic current compared with wild-type mice
• amphetamine-treated mice fail to exhibit a reduction in prepulse inhibition unlike similarly treated wild-type mice
• at P22 to 27, striatal long term depression cannot be induced by high-frequency stimulation unlike in wild-type mice

respiratory system
• under hypercapnic conditions in male, but not female, mice
• under hypoxic hypercapnic conditions in female, but not male mice
• under hypoxic hypercapnic conditions in female, but not male mice
• in male mice at day 2 and 8 of exposure to poikilocapnic hypoxia
• under hypoxic conditions in female, but not male mice
• under hypercapnic conditions in male, but not female, mice
• under hypoxic hypercapnic conditions in female, but not male mice
• at low levels of hypoxia in male mice

cardiovascular system
• mice exhibit increased blood pressure compared with wild-type mice
• during the first 5 minutes after AT1 antagonist treatment, mice exhibit a greater decrease in blood pressure than similarly treated wild-type mice
• phentolamine-treated mice exhibit a greater decrease in blood pressure than similarly treated wild-type mice
• BQ-788-treated mice exhibit a decrease in blood pressure unlike in similarly treated wild-type mice
• RES-701-1-treated mice exhibit a greater increase in blood pressure than similarly treated wild-type mice
• sarafotoxin S6c-treated mice exhibit a greater increase in blood pressure than similarly treated wild-type mice
• however, acute adrenalectomy results in normal blood pressure compared with similarly treated wild-type mice

homeostasis/metabolism
• before and after saline loading
• during the first 5 minutes after AT1 antagonist treatment, mice exhibit a greater decrease in blood pressure than similarly treated wild-type mice
• phentolamine-treated mice exhibit a greater decrease in blood pressure than similarly treated wild-type mice
• BQ-788-treated mice exhibit a decrease in blood pressure unlike in similarly treated wild-type mice
• RES-701-1-treated mice exhibit a greater increase in blood pressure than similarly treated wild-type mice
• sarafotoxin S6c-treated mice exhibit a greater increase in blood pressure than similarly treated wild-type mice
• however, mice respond normally to treatment with an ET(A) or V1 vasopressin receptor antagonist

renal/urinary system
• before and after saline loading
• before and after saline loading

growth/size/body
• in male, but not female, mice

taste/olfaction
N
• mice exhibit normal novel odor habituation and odor sensitivity


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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory