Phenotypes Associated with This Genotype

Genotype
MGI:4429483

• Allelic Composition: Tg(Myh6-Ppard)HEDpk/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:130750 )

N • mice exhibit normal ventricular weight and cardiac response to a high fat diet

increased cardiac muscle glycogen level ( J:130750 )

• increased glycogen level in myocardial cells

increased cardiac muscle cell glucose uptake ( J:130750 )

decreased cardiac muscle contractility ( J:130750 )

• without ventricular hypertrophy

abnormal response to cardiac infarction ( J:130750 )

• mice exhibit reduced ischemia/reperfusion injury compared with wild-type mice

decreased myocardial infarct size ( J:130750 )

• following ischemia/reperfusion injury, infarct area relative to area at risk is decreased compared to in similarly treated wild-type mice

homeostasis/metabolism

increased cardiac muscle glycogen level ( J:130750 )

• increased glycogen level in myocardial cells

abnormal response to cardiac infarction ( J:130750 )

• mice exhibit reduced ischemia/reperfusion injury compared with wild-type mice

decreased myocardial infarct size ( J:130750 )

• following ischemia/reperfusion injury, infarct area relative to area at risk is decreased compared to in similarly treated wild-type mice

muscle

increased cardiac muscle glycogen level ( J:130750 )

• increased glycogen level in myocardial cells

increased cardiac muscle cell glucose uptake ( J:130750 )

decreased cardiac muscle contractility ( J:130750 )

• without ventricular hypertrophy

cellular

increased cardiac muscle cell glucose uptake ( J:130750 )