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Phenotypes Associated with This Genotype
Genotype
MGI:4429452
Allelic
Composition
Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(WapTgfa)215Bri/0
Genetic
Background
B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (22 available)
Tg(WapTgfa)215Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

integument
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

neoplasm
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone
• a significantly earlier incidence of lung metastases
• at 8-months of age there are more small and large lung metastases

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
OMIM:600048
OMIM:605365
J:156750


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory