Mouse Genome Informatics
cx
    Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(WapTgfa)215Bri/0

B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• a significantly earlier incidence of lung metastases
• at 8-months of age there are more small and large lung metastases
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:156750