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Phenotypes Associated with This Genotype
Genotype
MGI:4429442
Allelic
Composition
Ppp1r3ctm1Ars/Ppp1r3c+
Genetic
Background
B6.129-Ppp1r3ctm1Ars
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Mouse lines carrying:
Ppp1r3ctm1Ars mutation (0 available); any Ppp1r3c mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• fasting serum leptin levels are elevated in older mutants (J:83297)
• fasting serum leptin levels are elevated in older mutants (J:83297)
• 180% increase in glucose transport into the epididymal adipose depot (J:83297)
• 180% increase in glucose transport into the epididymal adipose depot (J:83297)
• develop hyperinsulinemia with age; fasting serum insulin levels are elevated 2-fold at 1-2 months of age and 3-fold at 10 months of age (J:83297)
• develop hyperinsulinemia with age; fasting serum insulin levels are elevated 2-fold at 1-2 months of age and 3-fold at 10 months of age (J:83297)
• develop progressive glucose intolerance with age (J:83297)
• develop progressive glucose intolerance with age (J:83297)
• insulin-stimulated glycogen synthesis is reduced (J:83297)
• insulin-stimulated glycogen synthesis is reduced (J:83297)
• in a non-fasting state, mutants show a reduction in glycogen stores in adipose tissue (54% less), liver (42% less), heart (48% less), and skeletal muscle (26% less) (J:83297)
• in a fasted state, mutants show a 25% reduction in hepatic and heart glycogen (J:83297)
• in a non-fasting state, mutants show a reduction in glycogen stores in adipose tissue (54% less), liver (42% less), heart (48% less), and skeletal muscle (26% less) (J:83297)
• in a fasted state, mutants show a 25% reduction in hepatic and heart glycogen (J:83297)
• develop insulin resistance with age (J:83297)
• develop insulin resistance with age (J:83297)
• skeletal muscle of 18 month old mutants shows 30% increase in triglyceride content (J:83297)
• skeletal muscle of 18 month old mutants shows 30% increase in triglyceride content (J:83297)
• serum levels of fasting, but not non-fasting, triglycerides are increased by about 32% at 18 months of age (J:83297)
• serum levels of fasting, but not non-fasting, triglycerides are increased by about 32% at 18 months of age (J:83297)
• decrease in glycogen synthase activity in 1-2 month old mutants (J:83297)
• decrease in glycogen synthase activity in 1-2 month old mutants (J:83297)

muscle
• glucose uptake by white fiber quadriceps muscle is reduced by 35% in 3-4 month old mutants, however uptake into mixed fiber gastrocnemius muscle is not altered (J:83297)
• glucose uptake by white fiber quadriceps muscle is reduced by 35% in 3-4 month old mutants, however uptake into mixed fiber gastrocnemius muscle is not altered (J:83297)

cardiovascular system
• 25% increase in heart weight and heart/body weight ratio is seen in aged mutants (J:83297)
• 25% increase in heart weight and heart/body weight ratio is seen in aged mutants (J:83297)

cellular
• glucose uptake by white fiber quadriceps muscle is reduced by 35% in 3-4 month old mutants, however uptake into mixed fiber gastrocnemius muscle is not altered (J:83297)
• glucose uptake by white fiber quadriceps muscle is reduced by 35% in 3-4 month old mutants, however uptake into mixed fiber gastrocnemius muscle is not altered (J:83297)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:83297


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory