Analysis Tools
mortality/aging
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• mice die of dehydration within 24 hours of birth
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nervous system
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• at P1, the cerebral cortex lacks pial vasculature unlike in wild-type mice
• mice exhibit deficient vascular development in the superficial levels of the cortex near the marginal zone and cortical plate, and in the deep ventricular zone compared with wild-type mice
• mice exhibit defects in blood vessel density compared with wild-type mice
• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the cortex and forebrain while the distance between branch points is increased compared with wild-type mice
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hydrocephaly
(
J:86207
)
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• in neonates
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• at P1, the cerebral cortex is decreased in size compared to in wild-type mice
• at P1, the cerebral cortex lacks pial vasculature and exhibits cortical degeneration unlike in wild-type mice
• mice exhibit altered cortical neuronal organization compared with wild-type mice
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• at E13.5, mice exhibit neuron degeneration in the forebrain unlike wild-type mice
• mice exhibit neuron degeneration mainly in the subventricular zone unlike wild-type mice
• at E15.5, mice exhibit overt and anterior specific cortical neuronal degeneration unlike wild-type mice
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• by E15.5, mice exhibit an increase in neuron apoptosis in the cortex compared with wild-type mice
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• mice exhibit a 25% reduction in proliferating neurons compared with wild-type mice
• at E13.5, mice exhibit a 60% reduction in the number of periventricular neurons in the forebrain compared with wild-type mice
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cardiovascular system
|
• at P1, the cerebral cortex lacks pial vasculature unlike in wild-type mice
• mice exhibit deficient vascular development in the superficial levels of the cortex near the marginal zone and cortical plate, and in the deep ventricular zone compared with wild-type mice
• mice exhibit defects in blood vessel density compared with wild-type mice
• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the cortex and forebrain while the distance between branch points is increased compared with wild-type mice
|
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• at P1, sprouting angiogenesis into the inner plexiform layer is absent unlike in wild-type mice
|
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• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the cortex and forebrain while the distance between branch points is increased compared with wild-type mice
|
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• at E15.5, decreased vessel density and lack of sprouting is pronounced compared to in wild-type mice
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behavior/neurological
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• neonates exhibit spastic uncontrolled movements unlike wild-type mice
• neonates fail to remain upright when placed in a prone position unlike wild-type mice
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homeostasis/metabolism
dehydration
(
J:86207
)
|
• mice die of dehydration within 24 hours of birth
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craniofacial
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• as early as E17.5, mice exhibit abnormal cranial morphology compared with wild-type mice
• neonates exhibit altered cranial morphology compared to in wild-type mice
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vision/eye
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• at P1, sprouting angiogenesis into the inner plexiform layer is absent unlike in wild-type mice
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cellular
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• mice exhibit a 25% reduction in proliferating neurons compared with wild-type mice
• at E13.5, mice exhibit a 60% reduction in the number of periventricular neurons in the forebrain compared with wild-type mice
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