Phenotypes Associated with This Genotype

Genotype
MGI:4422199

• Allelic Composition: Vegfa^tm2Gne/Vegfa⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:86207 )

• retinas that lack a proper outer vascular plexus are also thin compared to in wild-type mice

abnormal retina vasculature morphology ( J:86207 )

• at P21, retinas lack a proper outer vascular plexus unlike in wild-type mice

abnormal retina outer nuclear layer morphology ( J:86207 )

• between P5 and 3 weeks of age, mice lack clear development of the outer retinal layer compared to in wild-type mice

abnormal retina outer plexiform layer morphology ( J:86207 )

• at P21, mice lack clear development of the outer plexiform layer unlike in wild-type mice

retina degeneration ( J:86207 )

retina gliosis ( J:86207 )

• at P7, some retinas exhibit an increase in microglia/macrophage numbers near the developing veins compared to in wild-type mice

nervous system

abnormal brain vasculature morphology ( J:86207 )

• vascular density and sprouting angiogenesis in the cerebellum, brain stem, and spinal cord are decreased compared to in wild-type mice

• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the forebrain and cortex while the distance between branch points is increased compared with wild-type mice

decreased brain size ( J:86207 )

• cortical brain size is reduced to in wild-type mice

decreased neuron number ( J:86207 )

• neuronal cellularity in the more superficial cortical layers I-III is decreased compared to in wild-type mice

cardiovascular system

abnormal brain vasculature morphology ( J:86207 )

• vascular density and sprouting angiogenesis in the cerebellum, brain stem, and spinal cord are decreased compared to in wild-type mice

• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the forebrain and cortex while the distance between branch points is increased compared with wild-type mice

abnormal retina vasculature morphology ( J:86207 )

• at P21, retinas lack a proper outer vascular plexus unlike in wild-type mice

abnormal vascular branching morphogenesis ( J:86207 )

• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the forebrain and cortex while the distance between branch points is increased compared with wild-type mice

decreased angiogenesis ( J:86207 )

• in the cerebellum, brain stem, and spinal cord