Phenotypes Associated with This Genotype

Genotype
MGI:4422185

• Allelic Composition: Stk3^tm1.1Yy/Stk3⁺; Stk4^tm1.1Yy/Stk4^tm1.1Yy
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:156541 )

• following adenoviral cre injection mice are protected from TNF alpha or Jo-2 antibody (a Fas agonist) induced mortality

liver/biliary system

abnormal liver physiology ( J:156541 )

• following adenoviral cre injection mice are protected from TNF alpha induced liver damage

decreased hepatocyte apoptosis ( J:156541 )

• following adenoviral cre injection mice are protected from TNF alpha or Jo-2 antibody (a Fas agonist) induced apoptosis

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:156541 )

• following adenoviral cre injection mice are mostly protected from TNF alpha induced increases in ALT levels

decreased circulating aspartate transaminase level ( J:156541 )

• following adenoviral cre injection mice are mostly protected from TNF alpha induced increases in ALT levels

abnormal response/metabolism to endogenous compounds ( J:156541 )

• following adenoviral cre injection mice are protected from TNF alpha induced liver damage

cellular

decreased hepatocyte apoptosis ( J:156541 )

• following adenoviral cre injection mice are protected from TNF alpha or Jo-2 antibody (a Fas agonist) induced apoptosis