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Phenotypes Associated with This Genotype
Genotype
MGI:4421776
Allelic
Composition
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Smim3tm1Anjm/Smim3+
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (11 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (2 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow (J:155870)
• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow (J:155870)
• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow (J:155870)
• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow (J:155870)
• a decrease in erythroid colony-forming units in the bone marrow (J:155870)
• a decrease in erythroid colony-forming units in the bone marrow (J:155870)
• there are a reduced numbers of circulating red blood cells (J:155870)
• there are a reduced numbers of circulating red blood cells (J:155870)
• in bone marrow and spleen (J:155870)
• in bone marrow and spleen (J:155870)
• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow (J:155870)
• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow (J:155870)

skeleton
• bone marrow dysplasia (J:155870)
• bone marrow dysplasia (J:155870)

Mouse Models of Human Disease
OMIM ID Ref(s)
Chromosome 5q Deletion Syndrome 153550 J:155870


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory