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Phenotypes Associated with This Genotype
Genotype
MGI:4421776
Allelic
Composition		 Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Smim3tm1Anjm/Smim3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (33 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased granulocyte monocyte progenitor cell number ( J:155870 )
• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow
• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow
decreased erythroid progenitor cell number ( J:155870 )
• a decrease in erythroid colony-forming units in the bone marrow
decreased erythrocyte cell number ( J:155870 )
• there are a reduced numbers of circulating red blood cells
decreased hematopoietic stem cell number ( J:155870 )
• in bone marrow and spleen
decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )
• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow

skeleton
abnormal bone marrow morphology ( J:155870 )
• bone marrow dysplasia

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chromosome 5q deletion syndrome DOID:0090016 OMIM:153550
 J:155870

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory