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Phenotypes Associated with This Genotype
Genotype
MGI:4421775
Allelic
Composition
Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (18 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (14 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• an elevated proportion of mast cells in the bone marrow
• a reduced number of cells are flushed from the femurs
• histological bone marrow sections have mild to high hypocellularity
• decreased granulocyte/macrophage colony-forming units
• by flow cytometry, a reduction in granulocyte-monocyte progenitors in the bone marrow
• a decreased number of erythroid colony-forming units
• a decreased number of megakaryocyte colony-forming units
• considerably fewer in the bone marrow by flow cytometry
• monolobulated megakaryocytes in the bone marrow
• pencil shaped cells are present in blood smears
• striking decrease in the common myeloid progenitor - megakaryocytic-erythroid progenitor lineage
• prominent erythroid dysplasia, dyserythropoiesis
• increase in the mean red blood cell distribution width
• in bone marrow and peripheral blood
• total granulocyte numbers are lower in the blood
• an elevated proportion of mast cells in the bone marrow
• modest
• in bone marrow and spleen
• by flow cytometry, a reduction in megakaryocytic-erythroid progenitors in the bone marrow

immune system
• total granulocyte numbers are lower in the blood
• an elevated proportion of mast cells in the bone marrow

Mouse Models of Human Disease
OMIM ID Ref(s)
Chromosome 5q Deletion Syndrome 153550 J:155870


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory