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Phenotypes Associated with This Genotype
Genotype
MGI:4421709
Allelic
Composition
Tg(CAG-SYVN1)1Tn/?
Genetic
Background
D1.Cg-Tg(CAG-SYVN1)1Tn
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 10 of 33 mutants develop spontaneous arthropathy, with joint swelling at 20 weeks of age
• joints show severe synovial cell hyperplasia and bone destruction

skeleton
• 10 of 33 mutants develop spontaneous arthropathy, with joint swelling at 20 weeks of age
• joints show severe synovial cell hyperplasia and bone destruction

cellular
• slight but significant decrease in apoptosis of synovial cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:86009


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory