Analysis Tools
mortality/aging
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• death by starvation at around 2 months of age
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behavior/neurological
| N |
• motor coordination and balance were largely normal in mutant mice
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• mutant mice, but not control mice (wild-type littermates), had major difficulties running at higher velocities on a treadmill
• limb coordination in neonatal mice, scored during air-stepping, was markedly different
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• mutant mice spent less time swimming
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• showed frequent twitching limb movements rarely observed in controls
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• swing times (flexion) were increased in all limbs, whereas stance time (extension) was increased in forelimbs
• alternating hindlimb movements were almost absent in mutant mice
• mutant mice may emphasize extension movements, resulting in a longer stride
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• significantly increased stride length in all limbs of mutant mice
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craniofacial
malocclusion
(
J:128347
)
nervous system
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• decreases in spinal commissural interneuron numbers in mutant mice compared to wild-type at E15
• 58% increase in the number of Wt1+ spinal cord neurons in mutant mice
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• analysis of central pattern generator output in the isolated neonatal spinal cord using drug-induced fictive locomotion shows that cords from mutant mice have uncoordinated and irregular firing rhythms as well as increased burst and interburst durations compared to control animals
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reproductive system
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• abnormalities in male sexual development
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skeleton
malocclusion
(
J:128347
)
growth/size/body
malocclusion
(
J:128347
)
