Phenotypes Associated with This Genotype

Genotype
MGI:4418678

• Allelic Composition: Tg(Fabp4-Ccl2)BYt/0
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating free fatty acids level ( J:110277 )

abnormal glucose homeostasis ( J:110277 )

• during hyperinsulinemic-euglycemic clamp analysis, glucose infusion is reduced 54% and glucose disappearance is reduced 21% compared to in similarly treated wild-type mice

increased circulating glucose level ( J:110277 )

• in fasted, but not fed, mice

abnormal gluconeogenesis ( J:110277 )

• during hyperinsulinemic-euglycemic clamp analysis, hepatic glucose production is increased compared to in similarly treated wild-type mice

• however, basal hepatic glucose production is normal

impaired glucose tolerance ( J:110277 )

insulin resistance ( J:110277 )

increased liver triglyceride level ( J:110277 )

adipose tissue

abnormal epididymal fat pad morphology ( J:110277 )

• the epididymal fat pad exhibits macrophage infiltration unlike in wild-type mice

liver/biliary system

increased liver triglyceride level ( J:110277 )