Mouse Genome Informatics
ht
    Tsk2/Tsk2+
involves: 101/H * C3H/He * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• at 7-8 months of age, heterozygotes display significant infiltration of mononuclear inflammatory cells in the lower dermis and in the adipose tissue septa
• some mononuclear inflammatory cells are already present in skin at 10 days of age

integument
• at 7-8 months of age, heterozygotes display significant infiltration of mononuclear inflammatory cells in the lower dermis and in the adipose tissue septa
• some mononuclear inflammatory cells are already present in skin at 10 days of age
• on average, the hydroxyproline (collagen) content in mutant skin samples from the interscapular region is 50% higher than that in wild-type samples
• densitometric analysis revealed that mutant skin samples contain 3-4-fold more collagen than wild-type samples; however, no qualitative differences in the populations of collagenous proteins are observed
• dermal thickness is significantly increased at 10 days and 7-8 months of age
• at 3 months of age, the mean interscapular skin thickness is 0.8 mm relative to 0.5 mm in wild-type mice
• heterozygotes develop a tight skin phenotype that is first evident in the interscapular region at 10-14 days of age
• at 7-8 months of age, heterozygotes display skin fibrosis, with excessive accumulation of densely packed connective tissue in the dermis, extending into the subdermal adipose tissue and into the panniculus carnosus
• excessive deposition of thick collagen fibers is already noted at 10 days of age

Mouse Models of Human Disease
OMIM IDRef(s)
Scleroderma, Familial Progressive 181750 J:31216