Phenotypes Associated with This Genotype

Genotype
MGI:4418180

• Allelic Composition: Mir206^tm1Eno/Mir206^tm1Eno; Tg(SOD1*G93A)^dl1Gur/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:155806 )

• average death at 244 days compared to 266 days in mice carrying the transgene alone

skeleton

kyphosis ( J:155806 )

muscle

skeletal muscle atrophy ( J:155806 )

• at 7.5 months of age

behavior/neurological

hindlimb paralysis ( J:155806 )

• accelerated compared to transgene alone

nervous system

abnormal neuromuscular synapse morphology ( J:155806 )

• neuromuscular junctions are disorganized and show imperfect colocalization of nerve and postsynaptic sites