Phenotypes Associated with This Genotype

Genotype
MGI:4417941

• Allelic Composition: Tg(KRT14-Fyn*)aJsey/0
• Genetic Background: involves: C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin squamous cell carcinoma incidence ( J:155536 )

• spontaneous squamous cell carcinomas (SCC) formation in 64 out of 176 transgenic mice

• develop multiple tumors between 5 and 8 weeks

• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization in SCC

• no metastasis after following for at least 6 months

integument

hyperkeratosis ( J:155536 )

• hyperkeratosis in punctate hyperkeratotic lesions

parakeratosis ( J:155536 )

• parakeratosis (retained nuclei in the stratum corneum) in punctate hyperkeratotic lesions

abnormal keratinocyte morphology ( J:155536 )

• cytologic atypia and architectural disorganization in hyperkeratotic plaques and lesions

• increased mitotic activity in hyperkeratotic plaques

• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization in SCC

abnormal keratinocyte differentiation ( J:155536 )

• keratinocyte dysplasia in punctate hyperkeratotic lesions

epidermal hyperplasia ( J:155536 )

• 135 out of 176 transgenic mice develop hyperkeratotic plaques within 4 days postnatal

• punctate (1-3 mm) hyperkeratotic lesions (resembling a human actinic keratosis) at 4 to 5 weeks

thick epidermis ( J:155536 )

• markedly thickened epidermis in hyperkeratotic plaques

increased skin squamous cell carcinoma incidence ( J:155536 )

• spontaneous squamous cell carcinomas (SCC) formation in 64 out of 176 transgenic mice

• develop multiple tumors between 5 and 8 weeks

• enlarged keratinocytes with nuclear atypia, mitotic activity, dermal invasion, and focal keratinization in SCC

• no metastasis after following for at least 6 months

cellular

abnormal keratinocyte differentiation ( J:155536 )

• keratinocyte dysplasia in punctate hyperkeratotic lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin squamous cell carcinoma		DOID:3151		J:155536