Mouse Genome Informatics
hm
    Slc1a1tm1Wst/Slc1a1tm1Wst
B6.129-Slc1a1tm1Wst
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• despite retinal ganglion cell loss and glaucomatous-like changes, mice exhibit normal intraocular pressure
• after 8 weeks, mice exhibit loss of retinal ganglion cells (RGCs) associated with oxidative stress unlike wild-type mice

homeostasis/metabolism
• in retinal ganglion cells treated with hydrogen peroxide

cellular
• retinal ganglion cells exhibit increased susceptibility to hydrogen peroxide compared with similarly treated wild-type cells

nervous system
• after 8 weeks, mice exhibit loss of retinal ganglion cells (RGCs) associated with oxidative stress unlike wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Glaucoma, Normal Tension, Susceptibility to 606657 J:124191