Phenotypes Associated with This Genotype

Genotype
MGI:4414944

• Allelic Composition: Gli1^tm2Alj/Gli1⁺; Gli2^tm1Alj/Gli2^tm1Alj; Gli3^Xt/Gli3^Xt
• Genetic Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:87948 )

• progenitors for motor neurons, V1 and V2 interneurons are present but intermixed indicating abnormal spatial patterning

abnormal neuronal precursor proliferation ( J:87948 )

• increased proliferation of ventral spinal cord progenitors at E10.5

absent floor plate ( J:87948 )

• floor plate progenitors are missing

abnormal neuronal precursor cell number ( J:87948 )

• incorrect positioning and number of V0-V2 and motor neuron progenitors at E9.5

abnormal spinal cord morphology ( J:87948 )

• ventral spinal cord is expanded resulting in a wavy appearance

abnormal motor neuron morphology ( J:87948 )

• distribution of motor neurons varies at E12.5

decreased motor neuron number ( J:87948 )

• reduction in the number of differentiated motor neurons but an increase in their progenitors

abnormal ventral interneuron morphology ( J:87948 )

• absence of V3 progenitors and interneurons, however V0-V2 cells are formed

• fewer V2, V1, and V0 interneurons are seen in the hindlimb

abnormal ventral interneuron 3 morphology ( J:87948 )

• absence of V3 progenitors and interneurons, however V0-V2 cells are formed

embryo

absent floor plate ( J:87948 )

• floor plate progenitors are missing

cellular

abnormal neuron differentiation ( J:87948 )

• progenitors for motor neurons, V1 and V2 interneurons are present but intermixed indicating abnormal spatial patterning

abnormal neuronal precursor proliferation ( J:87948 )

• increased proliferation of ventral spinal cord progenitors at E10.5