Phenotypes Associated with This Genotype

Genotype
MGI:4414840

• Allelic Composition: Slc4a11^{Gt(OST443317)Lex}/Slc4a11^{Gt(OST443317)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Collapse of the membranous labyrinth in the crista ampullaris and macula sacule of Slc4a11^{Gt(OST443317)Lex}/Slc4a11^{Gt(OST443317)Lex} mice

hearing/vestibular/ear

abnormal vestibular labyrinth morphology ( J:155513 )

• membranous labyrinth is collapsed

• cross sections of the crista ampullaris, macula utricle, and macula sacule are all normal

abnormal ear physiology ( J:155513 )

abnormal auditory brainstem response ( J:155513 )

• measurable response only at the highest intensity tested, 75db

• longer response latencies

• reduced central conduction time

reduced linear vestibular evoked potential ( J:155513 )

• reduced potentials with prolonged latencies for later peaks

• elevated thresholds

vision/eye

abnormal corneal epithelium morphology ( J:155513 )

• basal epithelial layer more columnar than for controls

• basal layer cell height higher than for controls

• cornea otherwise normal when examined under broad beam illumination