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Phenotypes Associated with This Genotype
Genotype
MGI:4414649
Allelic
Composition		 Ndptm1Lex/Y
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndptm1Lex mutation (0 available); any Ndp mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:154863 )
• retinal vasculature is extremely leaky and aberrant compared to in wild-type mice
• the inner and outer plexiform layers lack capillaries unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
blood vessel congestion ( J:154863 )
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice
increased vascular permeability ( J:154863 )
• retinal vasculature is extremely leaky compared to in wild-type mice

vision/eye
abnormal retina vasculature morphology ( J:154863 )
• retinal vasculature is extremely leaky and aberrant compared to in wild-type mice
• the inner and outer plexiform layers lack capillaries unlike in wild-type mice
• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice
• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory