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Phenotypes Associated with This Genotype
Genotype
MGI:4412051
Allelic
Composition
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0
Genetic
Background
B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
• at 4 months, mice exhibit tau plaques unlike wild-type mice
• tau deposits worsen with age

behavior/neurological
• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice
• in a novel arena at 2 and 12 months but not at 4 months

homeostasis/metabolism
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory