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Phenotypes Associated with This Genotype
Genotype
MGI:4412016
Allelic
Composition
Hbbd3th/Hbb+
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
Tg(LCR-HBA2,LCR-HBB)11Cos/0
Genetic
Background
involves: FVB/N * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbbd3th mutation (2 available); any Hbb mutation (25 available)
Tg(HBB-AR-HBA2,-HBB*)58Rub mutation (0 available)
Tg(LCR-HBA2,LCR-HBB)11Cos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• after 7 hours of water deprivation, mice exhibit a reduced capacity to concentrate urine compared with similarly treated wild-type mice

renal/urinary system
• after 7 hours of water deprivation, mice exhibit a reduced capacity to concentrate urine compared with similarly treated wild-type mice

hematopoietic system
• mice exhibit neonatal anemia
• under deoxygenated conditions, more than 17% of cells sickle in less than 50 seconds unlike wild-type cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Sickle Cell Anemia 603903 J:94190


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory