Mouse Genome Informatics
cx
    Hbbd3th/Hbb+
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
Tg(LCR-HBA2,LCR-HBB)11Cos/0

involves: FVB/N * Swiss Webster
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• after 7 hours of water deprivation, mice exhibit a reduced capacity to concentrate urine compared with similarly treated wild-type mice

renal/urinary system
• after 7 hours of water deprivation, mice exhibit a reduced capacity to concentrate urine compared with similarly treated wild-type mice

hematopoietic system
• under deoxygenated conditions, more than 17% of cells sickle in less than 50 seconds unlike wild-type cells
• mice exhibit neonatal anemia

Mouse Models of Human Disease
OMIM IDRef(s)
Sickle Cell Anemia 603903 J:94190