Phenotypes Associated with This Genotype

Genotype
MGI:4412009

• Allelic Composition: Trpm1^tm1Lex/Trpm1^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye physiology ( J:154776 )

• rod bipolar cell response is absent in mutants in response to chemically-stimulated light responses

• about 50% of cone ON-bipolar cells show no response to chemical stimulation by alpha-cyclopropyl-4-phosphonophenylglycine (CPPG) and the remaining cells activate a small transient current

abnormal eye electrophysiology ( J:154776 )

• spatial frequency and contrast sensitivity thresholds of the optokinetic response (OKR) are reduced 10% and 3-fold respectively compared to wild-type mice

• b-wave and oscillatory potentials are absent from both rod- and cone-mediated (scotopic and photopic) electroretinograms of mutants, whereas a-waves are identical to controls

• rod bipolar cell response is absent in mutants

• a capsaicin-sensitive current is present in some ON-bipolar cells in the mutant retina, but the magnitude is somewhat reduced compared to wild-type

abnormal cone electrophysiology ( J:154776 )

abnormal rod electrophysiology ( J:154776 )

abnormal vision ( J:154776 )

• vision is impaired as indicated by results of optokinetic response (OKR) tests, although not profoundly so