Phenotypes Associated with This Genotype

Genotype
MGI:4399133

• Allelic Composition: Zap70^tm2.1Weis/Zap70^tm2.1Weis; Tg(TcraH-Y,TcrbH-Y)71Vbo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell clonal deletion ( J:154166 )

• a substantial number of double positive and CD8 single positive thymocytes develop in male mutant mice unlike in transgenic mice wild type for Zap70

• three fold increase in total numbers of thymocytes in male mice with a nearly 40-fold increase in double positive thymocytes

abnormal positive T cell selection ( J:154166 )

• there were substantially fewer CD8+ HY-TCR+ thymocytes in female mice

immune system

abnormal T cell clonal deletion ( J:154166 )

• a substantial number of double positive and CD8 single positive thymocytes develop in male mutant mice unlike in transgenic mice wild type for Zap70

• three fold increase in total numbers of thymocytes in male mice with a nearly 40-fold increase in double positive thymocytes

abnormal positive T cell selection ( J:154166 )

• there were substantially fewer CD8+ HY-TCR+ thymocytes in female mice