About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4399132
Allelic
Composition		 Zap70m1Saka/Zap70tm2.1Weis
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70m1Saka mutation (1 available); any Zap70 mutation (55 available)
Zap70tm2.1Weis mutation (1 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell clonal deletion ( J:154166 )
• defects in the effectiveness of Mtv-8 and Mtv-9 induced clonal deletion in thymocyte cells bearing Vbeta5 and Vbeta11

immune system
abnormal T cell clonal deletion ( J:154166 )
• defects in the effectiveness of Mtv-8 and Mtv-9 induced clonal deletion in thymocyte cells bearing Vbeta5 and Vbeta11
decreased susceptibility to induced arthritis ( J:154166 )
• only 1 of 6 heterozygous mice develop mild arthritis during the 12-wk observation compared to the Zap70m1Saka homozygous mice which all have severe arthritis

skeleton
decreased susceptibility to induced arthritis ( J:154166 )
• only 1 of 6 heterozygous mice develop mild arthritis during the 12-wk observation compared to the Zap70m1Saka homozygous mice which all have severe arthritis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory