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Phenotypes Associated with This Genotype
Genotype
MGI:4397669
Allelic
Composition
Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1.1Naas mutation (0 available); any Kcnq2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice were born

nervous system
• mice exhibit spontaneous seizures with frequent generalized interictal cortical discharges, forepaw grooming, and clonic twitching unlike wild-type mice
• CA1 neurons exhibit decreased M-type potassium ion current amplitude and density compared with wild-type neurons

behavior/neurological
• mice exhibit spontaneous seizures with frequent generalized interictal cortical discharges, forepaw grooming, and clonic twitching unlike wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
benign neonatal seizures DOID:14264 OMIM:121200
OMIM:121201
OMIM:269720
J:154582


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory