Phenotypes Associated with This Genotype

Genotype
MGI:4397585

• Allelic Composition: Sort1^tm1Camo/Sort1^tm1Camo
• Genetic Background: B6.129X1-Sort1^tm1Camo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal lysosome morphology ( J:154468 )

• lysosome exhibit decreased prosaposin labeling compared with wild-type lysosomes

• however, mice do not exhibit any pathological manifestations of a lysosomal storage disorder

vision/eye

abnormal eye physiology ( J:157549 )

• mice subjected to intraocular injection of the pro form of nerve growth factor are protected from induced retinal ganglion cell death

homeostasis/metabolism

abnormal tumor necrosis factor level ( J:157549 )

• the pro form of nerve growth factor fails to induce TNF expression in retinas

immune system

abnormal tumor necrosis factor level ( J:157549 )

• the pro form of nerve growth factor fails to induce TNF expression in retinas