Phenotypes Associated with This Genotype

Genotype
MGI:4367886

• Allelic Composition: Apln^tm1Tq/Y
• Genetic Background: B6.129S6-Apln^tm1Tq

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased cardiac muscle contractility ( J:154303 )

♂ • mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice

abnormal myocardial fiber physiology ( J:154303 )

♂ • cardiomyocyte sarcomeric function is decreased with impaired velocity of contraction and relaxation compared to in wild-type mice

♂ • however, intracellular calcium is unchanged

homeostasis/metabolism

impaired exercise endurance ( J:154303 )

♂ • mice exhibit decreased exercise endurance compared with wild-type mice

decreased oxygen consumption ( J:154303 )

♂ • mice exhibit reduced maximal oxygen consumption compared with wild-type mice

muscle

decreased cardiac muscle contractility ( J:154303 )

♂ • mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice

behavior/neurological

impaired exercise endurance ( J:154303 )

♂ • mice exhibit decreased exercise endurance compared with wild-type mice